![]() 1 Likewise, the rate of increase or trend of serum creatinine levels can also indicate CKD. This perceived “normal” serum creatinine value actually corresponds to stage 3 CKD. For example, a 66-year-old man with a serum creatinine level of 1.4 mg/dL (to convert to μmol/L, multiply by 88.4) would have an estimated glomerular filtration rate (GFR) of 54 mL/min per 1.73 m 2. Normal creatinine values may vary among different laboratories, and some patients with serum creatinine levels within the “normal” range may have substantial reduction in kidney function. The evidence-based pearls in this article will help primary care physicians understand these concepts and avoid common pitfalls in the recognition and treatment of such disorders and guide their decision to refer their patients to a specialist.Ī “Normal” Serum Creatinine Level May Not Be Normal. 1 The evaluation of difficult-to-treat hypertension and kidney stones are additional skills that primary care physicians will need to acquire. Learning to recognize CKD in its earliest stage and understanding what measures to undertake to prevent its progression and associated complications are important goals developed by the Kidney Disease: Improving Global Outcomes (KDIGO) initiative. ![]() ![]() Outcomes associated with CKD are progression to kidney failure, cardiovascular disease, and premature death. ACEI = angiotensin-converting enzyme inhibitor ARB = angiotensin II receptor blocker BUN = blood urea nitrogen CKD = chronic kidney disease GFR = glomerular filtration rate LDL-C = low-density lipoprotein cholesterol NSAID = nonsteroidal anti-inflammatory drugĬhronic kidney disease (CKD) is a widespread public health problem with substantial morbidity and mortality. ![]()
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